The Child & Adolescent Mood Laboratory's work centers on understanding the ways in which cognitive, social, and biological factors interact in placing youth at risk for depression, and in developing evidence-based prevention and treatment programs for depression, anxiety and suicide among youth. Depression and suicide among youth are important clinical and public health concerns. Suicide is currently the third leading cause of death among adolescents, accounting for more deaths than all medical illnesses combined in this age group. Our objective is to develop evidence-based treatments for treating depression and reducing suicidality among children and adolescents.
Our current work include studies of predictors of relapse and recurrence after treatment for depression, gender differences in vulnerability for depression, neurocognitive substrates of depression among youth (with particular attention to reward systems) , and the application of cognitive bias modification strategies with vulnerable youth. In conjunction with colleagues at other universities, we have developed an internet based “resilience” program for at-risk teens. We have been very active in disseminating evidence-based procedures for treating depressed youth and preventing adolescent suicide.
The basic questions that our work seeks to address include:
How can we account for high rates of relapse after treatment of depression?
Are there biological, social or cognitive markers that can be used to identify youth who are most at risk for relapse?
How can we understand the very significant gender difference in relapse rates?
What social factors contribute to the development of maladaptive beliefs and vulnerability for depression among youth?
What are the neurological mechanisms by which CBT exerts its effects on mood?
Are there neurocognitive markers or predictors of response to treatment?
How can evidence-based approaches for treating depression and preventing suicide be disseminated to schools and communities?
- Randomized clinical trial of a primary care internet-based intervention to prevent adolescent depression: One-year outcomes. Saulsberry A, Marko-Holguin M, Blomeke K, Hinkle C, Fogel J, Gladstone T, Bell C, Reinecke M, Corden M, Van Voorhees BW..Journal of the Canadian Academy of Child and Adolescent Psychiatry. 2013 ; 22(2):106-117.
- Onset of alcohol or substance use disorders following treatment for adolescent depression. Curry J, Silva S, Rohde P, Ginsburg G, Kennard B, Kratochvil C, Simons A, Kirchner J, May D, Mayes T, Feeny N, Albano AM, Lavanier S, Reinecke M, Jacobs R, Becker-Weidman E, Weller E, Emslie G, Walkup J, Kastelic E, Burns B, Wells K, March J. Journal of consulting and clinical psychology. 2012 ; 80(2):299-312.
- Randomized controlled trial of primary care physician motivational interviewing versus brief advice to engage adolescents with an Internet-based depression prevention intervention: 6-month outcomes and predictors of improvement. Hoek W, Marko M, Fogel J, Schuurmans J, Gladstone T, Bradford N, Domanico R, Fagan B, Bell C, Reinecke MA, Van Voorhees BW. Translational Research. 2011;158(6):315-325.
- Parental marital discord and treatment response in depressed adolescents. Amaya MM, Reinecke MA, Silva SG, March JS..Journal of Abnormal Child Psychology. 2011; 39(3):401-411.
- Recovery and recurrence following treatment for adolescent major depression. Curry J, Silva S, Rohde P, Ginsburg G, Kratochvil C, Simons A, Kirchner J, May D, Kennard B, Mayes T, Feeny N, Albano AM, Lavanier S, Reinecke M, Jacobs R, Becker-Weidman E, Weller E, Emslie G, Walkup J, Kastelic E, Burns B, Wells K, March J. Archives of General Psychiatry. 2011 Mar;68(3):263-270.
- Extreme thinking in clinically depressed adolescents: Results from the Treatment for Adolescents with Depression Study (TADS). Jacobs RH, Reinecke MA, Gollan JK, Jordan N, Silva SG, March JS. Behaviour Research and Therapy. 2010 ;48(11):1155-1159.
- Ethnic Differences Among Adolescents Beginning Treatment for Depression. Stein GL, Curry JF, Hersh J, Breland-Noble A, March J, Silva SG, Reinecke MA, Jacobs R. Cultural Diversity and Ethnic Minority Psychology. 2010 ;16(2):152-158.
- Treating depression and oppositional behavior in adolescents. Jacobs RH, Becker-Weidman EG, Reinecke MA, Jordan N, Silva SG, Rohde P, March JS. Journal of Clinical Child and Adolescent Psychology. 2010 ;39(4):559-567.
- Social problem-solving among adolescents treated for depression. Becker-Weidman EG, Jacobs RH, Reinecke MA, Silva SG, March JS. Behaviour Research and Therapy. 2010;48(1):11-18.
- From prototype to product: Development of a primary care/internet based depression prevention intervention for adolescents (catch-it). Landback J, Prochaska M, Ellis J, Dmochowska K, Kuwabara SA, Gladstone T, Larson J, Stuart S, Gollan J, Bell C, Bradford N, Reinecke M, Fogel J, Van Voorhees BW. Community Mental Health Journal. 2009 ;45(5):349-354.
- The treatment for adolescents with depression study (TADS): Outcomes over 1 year of naturalistic follow-up. March J, Silva S, Curry J,et al. American Journal of Psychiatry. 2009 ;166(10):1141-1149.
Contact Mark Reinecke, PhD, for more information on the Child and Adolescent Mood Laboratory.