Our lab’s research is focused on the development of multidimensional and multimodal neuroimaging biomarkers using the tools of computational anatomy. Working with collaborators from engineering, mathematics, psychology and clinical specialties, we focus on the following major areas:
1. Mapping of Brain Structures using MRI: We develop automated pipelines to delineate brain structures based on simultaneous mappings of multiple structures from multiple atlases. This includes deep brain structures (such as the hippocampus, amygdala, thalamus, and basal ganglia) and cortical structures.
2. Complex Neuroimaging Biomarkers: We develop modeling and statistical approaches for the analysis of these maps. We develop frameworks for joint, integrated analyses of multidimensional, multimodal information based on the structural mapping of the brain.
3. Clinical Applications: We are interested in developing neuroimaging markers to characterize neuropsychiatric disorders, disease progression and prediction, and monitoring of treatment.
4. Big data Neuroscience: We are part of a network of collaborators that work on neuroscience workflow infrastructure, data sharing, data standards, data compatibility, and data harmonization.
5. Preclinical Applications: Neuroimaging of Animal Models.
For detailed information please review the below links.
- Neuroimaging and Applied Computational Anatomy Lab
- Research Projects and Grants
- Software and Data
Awards and Leadership Positions
Lei Wang, PhD, has served in multiple leadership positions, including:
- Ken and Ruth Davee Award for Innovative Investigations in Affective Disorders
- IDP Foundation Research Innovation Challenge Award
- Grant reviewer: NIH, CIHR, Alzheimer’s Association, The Netherlands Organisation for Health Research and Development, Czech Science Foundation
- Editorial board: Frontiers in Neuroscience: Brain Imaging Methods, Dataset Papers in Medicine: Radiology, Journal of Neurology and Psychology
Grants and Funding
- NIMH, NIA, NINR
- IDP Foundation, Alzheimer’s Association, Brain Research Foundation
- NUFSM Cognitive Neurology and Alzheimer Disease Center (CNADC) Pilot Grant
- Lisanne Jenkins, PhD: NARSAD Young Investigator Award
- Alexandra Apple: NRSA
- C. Paula Lewis-de los Angeles: NRSA, ACNP Travel Award
- Travel Fellowship for the Alzheimer’s Imaging Consortium (to Adam Christensen)
Alexandra Apple (Clinical Psychology)
Julie Peterson (Clinical Psychology)
C. Paula Lewis-de los Angeles (MSTP/NUIN)
Ivy Huang (NUFSM)
Shun Chin “Jim” Wu (visiting from National Defense Medical Center, School of Medicine, Taiwan)
Samantha Yang (Math and Neuroscience)
Kate Alpert (Software Developer)
Alex Kogan (Software Engineer, System Administrator)
Contact Lei Wang, PhD, Associate Professor in Neuroimaging and Applied Computational Anatomy Lab for more information.